An active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake (pKi = 7.35); the S-enantiomer of norfluoxetine is 20-fold more potent as an SSRI than the R-enantiomer (pKis = 7.86 versus 6.51

Norfluoxetine (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
57226-68-3
Storage:
-20
UN-No:
Non-Hazardous - /

Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35.{25776} The S-enantiomer of norfluoxetine has 20-times higher serotonin reuptake blocking potency than the R-enantiomer (pKis = 7.86 versus 6.51, respectively).{25777,25776}  

 

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Description

An active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake (pKi = 7.35); the S-enantiomer of norfluoxetine is 20-fold more potent as an SSRI than the R-enantiomer (pKis = 7.86 versus 6.51, respectively)

Formal name: γ-[4-(trifluoromethyl)phenoxy]-benzenepropanamine, monohydrochloride

Synonyms:  Desmethylfluoxetine

Molecular weight: 331.8

CAS: 57226-68-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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