A tetracyclic antidepressant that inhibits norepinephrine reuptake via the norepinephrine transporter (KD = 11.1 nM); inhibits serotonin 5-HT2A receptors (Ki = 51 nM) and binds the histamine H1 and α1-adrenergic receptors (KD = 2 and 90 nM

Maprotiline (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
10347-81-6
Storage:
-20
UN-No:
Non-Hazardous - /

Maprotiline is a norepinephrine reuptake inhibitor that binds the norepinephrine transporter with a KD value of 11.1 nM.{22877} Comparatively, it only weakly associates with serotonin and dopamine transporters (KDs = 5.8 and 1 µM, respectively).{22877} However, maprotiline moderately inhibits serotonin 5-HT2A receptors with a Ki value of 51 nM.{25805} Maprotiline has also been reported to bind the histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors with KD values of 2, 570, 90, and 350 nM, respectively.{25914} It has been used in the treatment of depression and also has been reported to possess sedative, anxiolytic, and sympathomimetic activities.{26037,25873}  

 

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Description

A tetracyclic antidepressant that inhibits norepinephrine reuptake via the norepinephrine transporter (KD = 11.1 nM); inhibits serotonin 5-HT2A receptors (Ki = 51 nM) and binds the histamine H1 and α1-adrenergic receptors (KD = 2 and 90 nM, respectively

Formal name: N-methyl-9,10H-ethanoanthracene-9-propanamine, monohydrochloride

Synonyms:  Deprilept|Ludiomil™

Molecular weight: 313.9

CAS: 10347-81-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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