A benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly; blocks normal rod shape formation and inhibits chromosome partitioning in E. coli

MreB Perturbing Compound A22 – 10 mg

Brand:
Cayman
CAS:
22816-60-0
Storage:
-20
UN-No:
Non-Hazardous - /

MreB is an actin-like protein expressed in bacteria.{25735} It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity.{25734} MreB perturbing compound A22 is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly.{25730} It blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml).{25731} It interferes with chromosome segregation in C. crescentus by preventing MreB binding to chromosomes.{25730} In V. cholerae, A22 prevents the development of normal cell shape and alters nucleoid morphology.{25733}  

 

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Description

A benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly; blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml); interferes with chromosome segregation in C. crescentus

Formal name: carbamimidothioic acid,(3,4-dichlorophenyl)methyl ester, monohydrochloride

Synonyms: 

Molecular weight: 271.6

CAS: 22816-60-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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