A cell-permeable

STAT5 Inhibitor – 10 mg

Brand:
Cayman
CAS:
285986-31-4
Storage:
-20
UN-No:
Non-Hazardous - /

Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.{19346,19347,5047} STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity).{25879} Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 µM).{25879} STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.{25879}  

 

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Description

A cell-permeable, nonpetidic nicotinoyl hydrazone that selectively suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity)

Formal name: 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide 3-pyridinecarboxylic acid

Synonyms:  Signal Transducers and Activators of Transcription 5

Molecular weight: 293.3

CAS: 285986-31-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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