A nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent to form interstrand crosslinks in DNA

Carmustine – 10 mg

Brand:
Cayman
CAS:
154-93-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent.{30627} It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis.{30628} Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase.{5822} Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.{30629}  

 

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Description

A nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent to form interstrand crosslinks in DNA, which leads to cancer cell cytotoxity and apoptosis; also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase

Formal name: N,N’-bis(2-chloroethyl)-N-nitroso-urea

Synonyms:  bis-Chloroethylnitrosourea|BCNU|Gliadel|NSC 409962

Molecular weight: 214.1

CAS: 154-93-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents

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