A cardiotonic steroid that inhibits theNa+/K+-ATPase transporter (Kds = 42

Bufalin – 5 mg

Brand:
Cayman
CAS:
465-21-4
Storage:
-20
UN-No:
Non-Hazardous - /

Bufalin is a cardiotonic steroid first isolated from toad venom and used in traditional Asian medicine.{29917,29914} It inhibits the Na+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the α1, α2, and α3 subunits, respectively).{29469} Intravenously administered bufalin is cleared rapidly, with a plasma half-life of 25 minutes in dogs and rats.{29913} Bufalin inhibits steroid receptor coactivator 1 (SRC-1) and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and in vivo.{25457} It can also impact the action and expression of several other proteins and kinases as well as induce apoptosis in various cancer cells.{29915,29916}  

 

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Description

A cardiotonic steroid that inhibits theNa+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the α1, α2, and α3 subunits, respectively); inhibits SRC-1 and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and in vivo

Formal name: (3β,5β)-3,14-dihydroxy-bufa-20,22-dienolide

Synonyms:  NSC 89595

Molecular weight: 386.5

CAS: 465-21-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Cardiomyopathy||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Lipid Biochemistry|Sterol Lipids

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