An inhibitor of parasitic and mammalian peroxiredoxins (T. gondii peroxiredoxin II (IC50 = 23 µM)

Conoidin A – 25 mg

Brand:
Cayman
CAS:
18080-67-6
Storage:
-20
UN-No:
Non-Hazardous - /

Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and act in redox signaling pathways. Increased expression of human peroxiredoxin is associated with cancer, cardiovascular dysfunction, and neurodegeneration. Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine on the enzyme.{25622,25624} It has been shown to inhibit peroxiredoxin II (IC50 = 23 µM) in the parasite T. gondii and peroxiredoxin I in the hookworm A. ceylanicum.{25622,25623,25624} At 5 µM, conoidin A can also inhibit the glucose oxidase-mediated hyperoxidation of mammalian peroxiredoxin I and II, but not peroxiredoxin III.{25622}  

 

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Description

An inhibitor of parasitic and mammalian peroxiredoxins (T. gondii peroxiredoxin II (IC50 = 23 µM), A. ceylanicum peroxiredoxin I, and mammalian peroxiredoxin I and II (5 µM))

Formal name: 2,3-bis(bromomethyl)-quinoxaline 1,4-dioxide

Synonyms: 

Molecular weight: 348

CAS: 18080-67-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Toxoplasmosis||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur

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