A selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM

SNC 80 – 25 mg

Brand:
Cayman
CAS:
156727-74-1
Storage:
-20
UN-No:
Non-Hazardous - /

SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor.{25516,25513,25515} It effectively activates µ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers.{25524} SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.{25516,25513,25514}  

 

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Description

A selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor; effectively activates µ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers

Formal name: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-benzamide

Synonyms:  NIH 10815

Molecular weight: 449.6

CAS: 156727-74-1

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Pain Research||Research Area|Neuroscience|Seizure Disorders

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