A mixture of ganglioside GM1 asialo with C18:1 and C20:1 sphingoid backbones; a component of cellular lipid rafts; a glycolipid receptor for P. aeruginosa flagellin; ligation stimulates defensive reponses in host cells including extracellular ATP release

Ganglioside GM1 Asialo Mixture – 1 mg

Brand:
Cayman
CAS:
71012-19-6
Storage:
-20
UN-No:
Non-Hazardous - /

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 (Item No. 19579) by neuraminidase.{25489,37774} Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody.{25488} The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals.{25489} Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones. [Matreya, LLC. Catalog No. 1064]  

 

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Description

A mixture of ganglioside GM1 asialo with C18:1 and C20:1 sphingoid backbones; a component of cellular lipid rafts; a glycolipid receptor for P. aeruginosa flagellin; ligation stimulates defensive reponses in host cells including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation; the percentage of ganglioside GM1 asialo-positive NK and CD8+ T cells in lung is increased in a mouse model of RSV infection compared with healthy animals; depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice

Formal name:

Synonyms:  ASGM1 Mixture|Asialo GM1 Mixture|Gangliotetraosylceramide Mixture

Molecular weight: 1,255.60

CAS: 71012-19-6

Purity: ≥98%

Formulation: A lyophilized powder

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|RSV Infections||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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