A mixture of ganglioside GD1a with C18:1 and C20:1 sphingoid backbones; found in brain

Ganglioside GD1a mixture (sodium salt) – 1 mg

Brand:
Cayman
CAS:
12707-58-3
Storage:
-20
UN-No:
Non-Hazardous - /

Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver.{25490} It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (TLR2), enabling the recruitment of TLR2 to lipid rafts when bound by a bacterial toxin.{25484} Ganglioside GD1a mixture contains ganglioside GD1a molecular species with C18:1 and C20:1 sphingoid backbones.  

 

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Description

A mixture of ganglioside GD1a with C18:1 and C20:1 sphingoid backbones; found in brain, erythrocytes, bone marrow, testis, spleen, and liver; can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis; increases endothelial cell proliferation; acts as a functional coreceptor for TLR2,

Formal name: ganglioside GD1a, disodium salt

Synonyms:  Ganglioside B1|Ganglioside G3

Molecular weight: 1,836.10

CAS: 12707-58-3

Purity: ≥98%

Formulation: A lyophilized powder

Product Type|Biochemicals|Lipids|Sphingolipids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Tumor Microenvironment||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Sphingolipids

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