A water-soluble

Becatecarin – 250 µg

Brand:
Cayman
CAS:
119673-08-4
Storage:
-20
UN-No:
Non-Hazardous - /

Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin.{25394} It intercalates into DNA, stabilizing the DNA-topoisomerase complex.{25390} This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis.{25390} Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo.{25391,25392} It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.{25393}  

 

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Description

A water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin; intercalates into DNA, stabilizing the DNA-topoisomerase complex, resulting in potent catalytic inhibition of both topoisomerases I and II, DNA cleavage and apoptosis

Formal name: 1,11-dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-b-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

Synonyms:  BMS 181176|BMY 27557|NSC 655649|XL 119

Molecular weight: 669.6

CAS: 119673-08-4

Purity: ≥98%

Formulation: A yellow solid

Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair|DNA Intercalating Agents||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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