A cell permeable analog of BAPTA that binds calcium only after the AM group is removed by cytoplasmic esterases; commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling; also inhibits Kv channels

BAPTA AM – 25 mg

Brand:
Cayman
CAS:
126150-97-8
Storage:
-20
UN-No:
Non-Hazardous - /

BAPTA (Item No. 11706) is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons.{22804,23059} BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm).{25230} BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases.{25228} It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling.{25229,25228,25226,25225} It can also be used in animals.{25228} BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).{25227}  

 

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Description

A cell permeable analog of BAPTA that binds calcium only after the AM group is removed by cytoplasmic esterases; commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling; also inhibits Kv channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively)

Formal name: N,N’-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-1,1′-bis[(acetyloxy)methyl] ester-glycine

Synonyms:  BAPTA Acetoxymethyl ester

Molecular weight: 764.7

CAS: 126150-97-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization

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