A cell imperbeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation; inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor (IC50 = 200 µM in vitro)

HNMPA – 5 mg

Brand:
Cayman
CAS:
132541-52-7
Storage:
-20
UN-No:
Non-Hazardous - /

HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity.{25669} It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities.{25669} HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 µM in vitro.{25669}  

 

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Description

A cell imperbeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation; inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor (IC50 = 200 µM in vitro)

Formal name: P-(hydroxy-2-naphthalenylmethyl)-phosphonic acid

Synonyms:  Hydroxy-2-naphthalenylmethyl Phosphonic Acid

Molecular weight: 238.2

CAS: 132541-52-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IGF-1R/InsR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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