A potent and selective β1-adrenergic receptor blocker (Ki = 47 nM for the β1 receptor

Metoprolol (succinate) – 250 mg

Brand:
Cayman
CAS:
98418-47-4
Storage:
-20
UN-No:
Non-Hazardous - /

Metoprolol is a potent and selective β1-adrenergic receptor blocker (Ki = 47 nM for the β1 receptor, compared with 3.0 and 10 μM for the β2 and β3 receptors, respectively).{25395,25151} This product is a racemic mixture of enantiomers that differ in their in vivo actions and metabolism.{25396} Metoprolol is predominantly metabolized by the cytochrome P450 (CYP) isoform CYP2D6, an enzyme with significant genetic heterogeneity in function.{25396,25398} The succinate salt of metoprolol is used in formulations intended for extended release of the compound.{25397} Beta-blockers, including metoprolol, have diverse applications in cardiology and vascular disease.{25397}  

 

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Description

A potent and selective β1-adrenergic receptor blocker (Ki = 47 nM for the β1 receptor, compared with 3.0 and 10 μM for the β2 and β3 receptors, respectively); predominantly metabolized by CYP2D6, an enzyme with significant genetic heterogeneity in function; has diverse applications in cardiology and vascular disease

Formal name: butanedioic acid, compd. with 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2)

Synonyms: 

Molecular weight: 326.4

CAS: 98418-47-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Heart|Arrhythmia

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