A flavonoid; reduces LPS- and IFN-γ-induced increases in iNOS protein levels and NO production in RAW 264.7 cells at 25

Nobiletin – 10 mg

Brand:
Cayman
CAS:
478-01-3
Storage:
-20
UN-No:
Non-Hazardous - /

Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.{52725,52726,52727} It reduces LPS- and IFN-γ-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM.{52725} Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively.{52726} Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks.{52727} It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.  

 

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Description

A flavonoid; reduces LPS- and IFN-γ-induced increases in iNOS protein levels and NO production in RAW 264.7 cells at 25, 50, and 100 µM; decreases proliferation of A549, B16/4A5, CCRF-HSB-2, and TGBC11TKB cancer cell lines (IC50s = 22, 18, 13, and 8.3 µM, respectively); reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet at 0.3% w/w; inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model

Formal name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one

Synonyms:  NSC 618903|NSC 76751

Molecular weight: 402.4

CAS: 478-01-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen|iNOS

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