A potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM); lowers both total cholesterol and LDL cholesterol in animals and humans

Pitavastatin (calcium salt) – 50 mg

Brand:
Cayman
CAS:
147526-32-7
Storage:
-20
UN-No:
Non-Hazardous - /

The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis.{20936} Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM).{25250} It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans.{25248} Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.{25248} Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure.{25249,25247}  

 

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Description

A potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM); lowers both total cholesterol and LDL cholesterol in animals and humans

Formal name: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid, monocalcium salt

Synonyms:  Itabastatin|Itavastatin|NK 104

Molecular weight: 881

CAS: 147526-32-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins

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