A potent and reversible proteasome inhibitor

(S)-MG115 – 5 mg

Brand:
Cayman
CAS:
133407-86-0
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM).{13817} It reduces the degradation of ubiquitin-conjugated proteins in extracts.{13817} (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53.{13817,25785,13815} Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.{13815,25786,25784}  

 

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Description

A potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM); reduces the degradation of ubiquitin-conjugated proteins in extracts; blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins

Formal name: N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-L-leucinamide

Synonyms: 

Molecular weight: 461.6

CAS: 133407-86-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cancer|Transcription Factors|p53||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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