A selective inhibitor of cFMS kinase (IC50 = 0.03 μM) that prevents CSF-1-induced monocyte growth with an IC50 value of 0.14 μM; at 75-100 mg/kg

GW 2580 – 5 mg

Brand:
Cayman
CAS:
870483-87-7
Storage:
-20
UN-No:
Non-Hazardous - /

cFMS kinase is the cellular homolog of the v-FMS oncogene product of the Susan McDonough strain of the feline sarcoma virus. It can autophosphorlyate colony-stimulating factor (CSF-1), which promotes the survival, proliferation, and differentiation of mononuclear phagocytes. GW 2580 selectively inhibits cFMS kinase (IC50 = 0.03 μM), preventing CSF-1-induced monocyte growth with an IC50 value of 0.14 μM.{25081} At 75-100 mg/kg, it has been shown to inhibit joint connective tissue and bone degradation in mouse models of arthritis.{25081}  

 

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Description

A selective inhibitor of cFMS kinase (IC50 = 0.03 μM) that prevents CSF-1-induced monocyte growth with an IC50 value of 0.14 μM; at 75-100 mg/kg, inhibits joint connective tissue and bone degradation in mouse models of arthritis

Formal name: 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine

Synonyms: 

Molecular weight: 366.4

CAS: 870483-87-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity

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