A potent HDAC inhibitor that inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM; ineffective against HDAC4 (IC50 = >1

CAY10683 – 5 mg

Brand:
Cayman
CAS:
1477949-42-0
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10683 is a potent histone deacetylase (HDAC) inhibitor isolated from the cyanobacterium Symploca.{24818} It inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM, respectively, and is without effect against HDAC4 (IC50 = >1,000 nM).{24818} CAY10683 inhibits the growth of HCT116 colon cancer cells and HuT-78 cutaneous T cell lymphoma cells (GI50 = 29.4 and 1.4 μM, respectively) more effectively than human dermal fibroblasts (GI50 = >100 μM).{24818}  

 

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Description

A potent HDAC inhibitor that inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM; ineffective against HDAC4 (IC50 = >1,000 nM); inhibits the growth of HCT116 cells and HuT-78 cells (GI50 = 29.4 and 1.4 μM, respectively) more effectively than human dermal fibroblasts (GI50 = >100 μM)

Formal name: N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

Synonyms:  Santacruzamate A

Molecular weight: 278.4

CAS: 1477949-42-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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