An inhibitor of UCH-L1 activity (IC50 = 0.88 Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM); leads to cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway

LDN-57444 – 5 mg

Brand:
Cayman
CAS:
668467-91-2
Storage:
-20
UN-No:
Non-Hazardous - /

The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain.{25201} LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM).{25200} Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.{25201}  

 

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Description

An inhibitor of UCH-L1 activity (IC50 = 0.88 Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM); leads to cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway

Formal name: 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)

Synonyms:  Ubiquitin C-terminal Hydrolase L1 Inhibitor|UCH-L1 Inhibitor

Molecular weight: 397.6

CAS: 668467-91-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Neuroscience

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