A benzylidene lactam compound that prevents the synthesis of inducible Hsps Hsp105

Heat Shock Protein Inhibitor I – 5 mg

Brand:
Cayman
CAS:
218924-25-5
Storage:
-20
UN-No:
Non-Hazardous - /

Heat shock protein (Hsp) inhibitor I is a benzylidene lactam compound that prevents the synthesis of inducible Hsps Hsp105, Hsp72, and Hsp40. At 100 μM, it can inhibit the development of thermotolerance in COLO 320 DM cells.{25048} Its effects on thermotolerance have been studied in the context of clinical fractionated hyperthermia as a modality of cancer therapy.{25049}  

 

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Description

A benzylidene lactam compound that prevents the synthesis of inducible Hsps Hsp105, Hsp72, and Hsp40; at 100 μM, inhibits the development of thermotolerance in COLO 320 DM cells

Formal name: 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde

Synonyms:  Hsp Inhibitor I|KNK 437

Molecular weight: 245.2

CAS: 218924-25-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer||Research Area|Cell Biology|Cellular Chaperones

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