A histamine H1 receptor antagonist (Ki = 0.4 nM; IC50 = 45 nM) that does not cross the blood brain barrier; 10 μM inhibits T cell proliferation and the production of Th2-type pro-inflammatory cytokines by macrophages

Ebastine – 5 g

Brand:
Cayman
CAS:
90729-43-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ebastine is a potent second generation histamine H1 receptor antagonist (Ki = 0.4 nM; IC50 = 45 nM) that does not cross the blood brain barrier.{24986} It undergoes extensive first-pass metabolism by hepatic cytochrome P450 3A4 into its active carboxylic acid metabolite, carebastine, which exerts most of the pharmacological effects.{24985} At 10 μM, ebastine has been shown to inhibit T cell proliferation and the production of Th2-type pro-inflammatory cytokines by macrophages.{24987}  

 

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Description

A histamine H1 receptor antagonist (Ki = 0.4 nM; IC50 = 45 nM) that does not cross the blood brain barrier; 10 μM inhibits T cell proliferation and the production of Th2-type pro-inflammatory cytokines by macrophages

Formal name: 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone

Synonyms:  LAS-W 090|RP 64305

Molecular weight: 469.7

CAS: 90729-43-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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