An inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM); prevents the expression of oncogenic proteins in mammalian cancer cells

4EGI-1 – 25 mg

Brand:
Cayman
CAS:
315706-13-9
Storage:
-20
UN-No:
Non-Hazardous - /

In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation.{25211} A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G.{25211} 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM).{25208} It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation.{25208} 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis.{25208,25207,25213} Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders.{25212,25210,25206} 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.{25209}  

 

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Description

An inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM); prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis; blocks translation in some viruses that do not require eIF4E or a cap structure for initiation

Formal name: α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

Synonyms:  eIF4E/eIF4G Interaction Inhibitor

Molecular weight: 451.3

CAS: 315706-13-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis

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