A potent inhibitor of the glycolysis enzyme PFKFB3

YZ9 – 5 mg

Brand:
Cayman
CAS:
6093-71-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cells that are rapidly proliferating or hypoxic emphasize glycolysis over oxidative phosphorylation to meet energy needs.{22136,26415} During glycolysis, fructose 6-phosphate (F6P) is phosphorylated by 6-phosphofructo-2-kinases (PFKs) to generate fructose 2,6-bisphosphate. As PFK family members also mediate the reverse reaction as fructose 2,6-bisphosphatases, these enzymes are known as PFKFB family members. Notably, PFKFB3 is overexpressed in a wide variety of cancer cell lines.{27006} YZ9 is a potent inhibitor of PFKFB3, with an IC50 value of 183 nM in vitro.{27006} It avidly competes with F6P at PFKFB3 (Ki = 94 nM).{27006} YZ9 is also cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM.{27006}  

 

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Description

A potent inhibitor of the glycolysis enzyme PFKFB3, with an IC50 value of 183 nM in vitro; avidly competes with F6P at PFKFB3 (Ki = 94 nM); cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM

Formal name: 7-hydroxy-2-ozo-2H-1-benzopyran-3-carboxylic acid, ethyl ester

Synonyms:  7-hydroxycoumarin-3-Carboxylic Acid ethyl ester

Molecular weight: 234.2

CAS: 6093-71-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling||Research Area|Cancer|Metabolism||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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