Selectively activates BKCa channels

NS 11021 – 5 mg

Brand:
Cayman
CAS:
956014-19-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1).{32423} It is selective for BKCa and is thought to bind directly the ɑ subunit.{32423} NS 11021 has been shown to relax intracavernous arterial rings and corpus cavernosum strips in vitro and to enhance erectile responses in intact rats.{32424}  

 

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Description

Selectively activates BKCa channels, binding directly the ɑ subunit; relaxes intracavernous arterial rings and corpus cavernosum strips in vitro and to enhance erectile responses in intact rats

Formal name: N’-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea

Synonyms: 

Molecular weight: 511.2

CAS: 956014-19-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cardiovascular System|Vasculature|Vasodilation

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