A gold-thiol complex with diverse biological activities; inhibits thioredoxin reductase (IC50 = 0.2 µM)

Auranofin – 100 mg

Brand:
Cayman
CAS:
34031-32-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Auranofin is a gold-thiol complex with diverse biological activities.{25302,25305,61148} It inhibits thioredoxin reductase (IC50 = 0.2 µM), increases oxidation of mitochondrial peroxiredoxin 3 (PRDX3), and induces apoptosis in Jurkat T cells.{25302} Auranofin reduces the production of IL-6 and activation of JAK1 and JAK2, as well as inhibits nuclear translocation of NF-kB, in primary human synoviocytes.{25305} It is active against P. falciparum and S. mansoni in vitro when used at concentrations ranging from 1 to 10 µM. Auranofin (2 mg/kg per day) reduces the number of peripheral blood mononuclear cells (PBMCs) containing viral DNA and delays viral rebound in macaques infected with the mac251 strain of simian immunodeficiency virus (SIV).{61148}  

 

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Description

A gold-thiol complex with diverse biological activities; inhibits thioredoxin reductase (IC50 = 0.2 µM), increases oxidation of mitochondrial PRDX3, and induces apoptosis in Jurkat T cells; reduces the production of IL-6 and activation of JAK1 and JAK2, as well as inhibits nuclear translocation of NF-kB, in primary human synoviocytes; active against P. falciparum and S. mansoni in vitro from 1-10 µM; reduces the number of PBMCs containing viral DNA and delays viral rebound in macaques infected with the mac251 strain of SIV at 2 mg/kg per day

Formal name: [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-gold

Synonyms:  NSC 321521|Ridauragold thiol|SKF 39162

Molecular weight: 678.5

CAS: 34031-32-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Infectious Disease|Parasitic Diseases|Schistosomiasis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Thioredoxin

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