An ACE inhibitor (IC50 = 23 nM for the rabbit lung enzyme); inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM

Captopril – 1 g

Brand:
Cayman
CAS:
62571-86-2
Storage:
-20
UN-No:
Non-Hazardous - /

Captopril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 23 nM for the rabbit lung enzyme).{42208,52244} It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively) but not those induced by angiotensin II, histamine, acetylcholine, serotonin (5-HT), or prostaglandin E1 (PGE1; IC50s = >10 µM for all).{52244} Captopril (0.1-1 mg/kg) inhibits angiotensin I-induced pressor responses in conscious normotensive rats.{42208} It reduces mean blood pressure in two kidney-one clip renal hypertensive (2K-1C) rats and spontaneously hypertensive rats (SHRs). Captopril also reduces cytopathogenicity induced by herpes simplex virus 1 (HSV-1) in SH-SY5Y human neuroblastoma cells.{61145} Formulations containing captopril have been used in the treatment of hypertension, congestive heart failure, and diabetic nephropathy.  

 

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Description

An ACE inhibitor (IC50 = 23 nM for the rabbit lung enzyme); inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively); angiotensin I-induced pressor responses in conscious normotensive rats; reduces mean blood pressure in 2K-1C rats and SHRs; reduces HSV-1-induced cytopathogenicity in SH-SY5Y human neuroblastoma cells

Formal name: 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline

Synonyms:  SA 333|SQ 14,225

Molecular weight: 217.3

CAS: 62571-86-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease|Diabetic Nephropathy||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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