A natural (ADEP) antibiotic that constitutively activates the bacterial protease ClpP

A-54556A – 5 mg

Brand:
Cayman
CAS:
95398-45-1
Storage:
-20
UN-No:
Non-Hazardous - /

A-54556A is a natural acyldepsipeptide (ADEP) antibiotic isolated from the fermentation broth of S. hawaiiensis.{24688} Like other ADEP antibiotics, A-54556A binds to the ATP-dependent Clp protease proteolytic subunit ClpP, resulting in constitutive activation of this bacterial protease.{27768,27766,27765} This leads to uncontrolled proteolysis, inhibition of bacterial cell division, and, ultimately, cell death.{24688,27767} A-54556A preferentially targets Gram-positive bacteria, including staphylococci, streptococci, and enterococci, with minimum inhibitory concentration values in the submicrogram/milliliter range.{27767} ADEP antibiotics are effective against chronic infections as they are able to eradicate chronic biofilm infections, particularly when combined with rifampicin.{24689}  

 

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Description

A natural (ADEP) antibiotic that constitutively activates the bacterial protease ClpP, resulting in uncontrolled proteolysis, inhibition of bacterial cell division, and, ultimately, cell death; preferentially targets Gram-positive bacteria

Formal name: (4R)-N-[(2E,4E,6E)-1-oxo-2,4,6-octatrien-1-yl]-L-phenylalanyl-L-seryl-L-prolyl-N-methyl-L-alanyl-L-alanyl-4-methyl-L-proline, (6→2)-lactone

Synonyms:  A-54556 Factor A|ADEP 1

Molecular weight: 718.9

CAS: 95398-45-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Activators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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