An inhibitor of PHD2 and PHD3 (IC50s = 1.1 and 0.39 μM

Vadadustat – 50 mg

Brand:
Cayman
CAS:
1000025-07-9
Storage:
-20
UN-No:
Non-Hazardous - /

Vadadustat is an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) and PHD3 (IC50s = 1.1 and 0.39 μM, respectively).{51165} It stabilizes HIF-1α in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.  

 

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Description

An inhibitor of PHD2 and PHD3 (IC50s = 1.1 and 0.39 μM, respectively); stabilizes HIF-1α in mouse hepatocyte nuclear extracts; increases erythropoietin levels in mouse serum at 50 and 100 mg/kg

Formal name: N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-glycine

Synonyms:  AKB6548|PG-1016548

Molecular weight: 306.7

CAS: 1000025-07-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Blood|Erythrocytes & Hemoglobin

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