An L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM

(R)-(+)-BAY-K-8644 – 10 mg

Brand:
Cayman
CAS:
98791-67-4
Storage:
-20
UN-No:
Non-Hazardous - /

BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions.{24672,24674,24673} (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM.{24675,24676,24673} Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.{24674}  

 

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Description

An L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM

Formal name: (4R)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid

Synonyms:  NI 105|R 4407

Molecular weight: 356.3

CAS: 98791-67-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience

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