A broad-spectrum caspase inhibitor

Q-VD-OPH – 1 mg

Brand:
Cayman
CAS:
1135695-98-5
Storage:
-20
UN-No:
Non-Hazardous - /

Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µM.{24511,24509} It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK (Item No. 14463) and Boc-D-FMK (Item No. 16118).{24511,24509} Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis.{24510,24507} This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.{24508}  

 

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Description

A broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µM; more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK; can be used in vivo

Formal name: (3S)-5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid

Synonyms:  Quinoline-Val-Asp-Difluorophenoxymethyl Ketone

Molecular weight: 513.5

CAS: 1135695-98-5

Purity: ≥95% (mixture of tautomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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