An MCT1 inhibitor; blocks pyruvate transport in rat heart mitochondria (IC50 = 1.5 μM); commonly used as a matrix to facilitate peptide ionization in MALDI-TOF mass spectrometry applications

α-Cyano-4-hydroxycinnamic Acid – 5 g

Brand:
Cayman
CAS:
28166-41-8
Storage:
-20
UN-No:
Non-Hazardous - /

α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 = 1.5 μM).{28011} It is commonly used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications.{50291,45375}  

 

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Description

An MCT1 inhibitor; blocks pyruvate transport in rat heart mitochondria (IC50 = 1.5 μM); commonly used as a matrix to facilitate peptide ionization in MALDI-TOF mass spectrometry applications

Formal name: 2-cyano-3-(4-hydroxyphenyl)-2-propenoic acid

Synonyms:  CHC|NSC 173138|α-CHCA

Molecular weight: 189.2

CAS: 28166-41-8

Purity: ≥98%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Mitochondrial Biology

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