An inhibitor of LAT1 that blocks the uptake of L-leucine with an IC50 value of 131.5 µM and can inhibit all members of the LAT family at a concentration of 10 mM; suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation

BCH – 100 mg

Brand:
Cayman
CAS:
20448-79-7
Storage:
-20
UN-No:
Non-Hazardous - /

The L-type amino acid transporters (LATs) are Na+-dependent neutral amino acid transporters.{30008} They include four members in two sub-families, with LAT1 and LAT2 belonging to solute carrier (SLC) family 7 and LAT3 and LAT4 being members of SLC43.{30008} LAT1 is overexpressed in many tumors and contributes to ribosome biogenesis and cell growth by supporting mTOR complex 1 (mTORC1) signaling.{15559} BCH is an inhibitor of LAT1 that blocks the uptake of L-leucine with an IC50 value of 131.5 µM.{30005,30007} It can inhibit all members of the LAT family at a concentration of 10 mM.{30008} In addition to eliminating the uptake of neutral amino acids, BCH suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation.{30008,15559} LAT1 is also essential for the uptake of amino acid-related compounds, like L-DOPA (Item No. 13248), through the blood-brain barrier, and this can be inhibited by BCH.{30007,30006}  

 

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Description

An inhibitor of LAT1 that blocks the uptake of L-leucine with an IC50 value of 131.5 µM and can inhibit all members of the LAT family at a concentration of 10 mM; suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation

Formal name: 2-amino-bicyclo[2.2.1]heptane-2-carboxylic acid

Synonyms:  2-amino-2-Norbornanecarboxylic Acid

Molecular weight: 155.2

CAS: 20448-79-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling

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