An antagonist of GPR55; inhibits LPI-induced GPR55 signaling (EC50 = 1.076 µM in U2OS cells overexpressing GPR55); inhibits LPI-induced ERK1/2 phosphorylation (IC50 = 328 nM) and receptor-dependent PKCβII translocation at 30 µM

ML-191 – 1 mg

Brand:
Cayman
CAS:
931695-79-3
Storage:
-20
UN-No:
Non-Hazardous - /

ML-191 is an antagonist of GPR55.{24561} It inhibits GPR55 signaling induced by lysophosphatidylinositol (LPI; EC50 = 1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50 = 328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 µM.{24561}  

 

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Description

An antagonist of GPR55; inhibits LPI-induced GPR55 signaling (EC50 = 1.076 µM in U2OS cells overexpressing GPR55); inhibits LPI-induced ERK1/2 phosphorylation (IC50 = 328 nM) and receptor-dependent PKCβII translocation at 30 µM

Formal name: 5-phenyl-3-(1-(1-(p-tolyl)cyclopropane-1-carbonyl)piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one

Synonyms:  CCG-152883|CID-23612552

Molecular weight: 403.5

CAS: 931695-79-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Cannabinoid Research

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