An allosteric

ML-161 – 25 mg

Brand:
Cayman
CAS:
423735-93-7
Storage:
-20
UN-No:
Non-Hazardous - /

ML-161 is an allosteric, reversible inhibitor of proteinase-activated receptor 1 (PAR1) on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 µM.{24559} It blocks platelet activation induced by thrombin as well as by SFLLRN but not by PMA (Item No. 10008014), U-46619 (Item No. 16450), or collagen.{24559}  

 

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Description

An allosteric, reversible inhibitor of PAR1 on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 µM; also blocks platelet activation induced by thrombin but not by PMA, U-46619, or collagen

Formal name: 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide

Synonyms:  AG-670|CID-1048267

Molecular weight: 361.2

CAS: 423735-93-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cardiovascular System|Blood|Thrombosis

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