The first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2

ML-090 – 10 mg

Brand:
Cayman
CAS:
531-46-4
Storage:
-20
UN-No:
Non-Hazardous - /

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer.{24571} ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ≥ 10 µM) and xanthine oxidase (IC50 = 3.5 µM).{24571}  

 

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Description

The first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ≥ 10 µM) and xanthine oxidase (IC50 = 3.5 µM)

Formal name: 5,12-dihydro-quinoxalino[2,3-b]quinoxaline

Synonyms:  CCG-44699|CID-616479|Fluoflavin|NSC 179821

Molecular weight: 234.3

CAS: 531-46-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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