A potent

Roflumilast – 25 mg

Brand:
Cayman
CAS:
162401-32-3
Storage:
-20
UN-No:
Non-Hazardous - /

Type 4 cyclic nucleotide phosphodiesterase (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP.{22523} Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50 = 50 values against other PDE forms being greater than 10 μM.{24530} Roflumilast demonstrates good bioavailability and has applications in respiratory diseases, including asthma and chronic obstructive pulmonary disease.{18127,23597}  

 

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Description

A potent, cell-permeable inhibitor of PDE4 (IC50 = 50 values against other PDE forms being greater than 10 μM

Formal name: 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-benzamide

Synonyms:  B 9302-107|BY 217|BYK 20869

Molecular weight: 403.2

CAS: 162401-32-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema

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