A clickable form of puromycin; inhibits protein synthesis in rabbit reticulocyte lysates and HEK293T cells from 1-25 µM; incorporated into nascent polypeptide chains where it forms covalent adducts and terminates chain elongation on the ribosome; has been used in combination with fluorescent azides to image nascent proteins in various cells

O-Propargyl-puromycin – 500 µg

Brand:
Cayman
CAS:
1416561-90-4
Storage:
-20
UN-No:
Non-Hazardous - /

O-Propargyl-puromycin (OP-puro) is a clickable form of the protein synthesis inhibitor puromycin (Item No. 13884).{26288} It inhibits protein synthesis in rabbit reticulocyte lysates and HEK293T cells when used at concentrations ranging from 1 to 25 µM. OP-puro is incorporated into nascent polypeptide chains where it forms covalent adducts and terminates chain elongation on the ribosome. It has been used in combination with fluorescent azides to image nascent proteins in various cells.{26288,46902}  

 

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Description

A clickable form of puromycin; inhibits protein synthesis in rabbit reticulocyte lysates and HEK293T cells from 1-25 µM; incorporated into nascent polypeptide chains where it forms covalent adducts and terminates chain elongation on the ribosome; has been used in combination with fluorescent azides to image nascent proteins in various cells

Formal name: 3′-[[(2S)-2-amino-1-oxo-3-[4-(2-propyn-1-yloxy)phenyl]propyl]amino]-3′-deoxy-N,N-dimethyl-adenosine

Synonyms:  OPP|OP-puro

Molecular weight: 495.5

CAS: 1416561-90-4

Purity: ≥98%

Formulation: A crystalline solid

Application|Click Chemistry||Product Type|Biochemicals|Labeling & Detection|Reactive Probes||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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