A sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles; selectively inhibits the growth of influenza A and B viruses in plaque reduction assays (IC50s = 5-14 nM) and to directly inhibit influenza A and B virus neuraminidases (IC50s = 0.6-7.9 nM in vitro)

Zanamivir – 5 mg

Brand:
Cayman
CAS:
139110-80-8
Storage:
-20
UN-No:
Non-Hazardous - /

Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.{24439} It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50 values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50 values ranging from 0.6 to 7.9 nM in vitro.{24439} Intranasal zanamivir administration at 0.4 mg/kg twice daily can reduce mortality and viral titers in lung homogenates of mice infected with influenza.{24439}  

 

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Description

A sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles; selectively inhibits the growth of influenza A and B viruses in plaque reduction assays (IC50s = 5-14 nM) and to directly inhibit influenza A and B virus neuraminidases (IC50s = 0.6-7.9 nM in vitro)

Formal name: 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid

Synonyms:  GG 167|GR 121167X

Molecular weight: 332.3

CAS: 139110-80-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Neuraminidase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza

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