A potent anticarcinogen that effectively induces phase I and II detoxifying enzymes and has been linked to activating the transcription factors Nrf2 and CAR

Oltipraz – 1 g

Brand:
Cayman
CAS:
64224-21-1
Storage:
-20
UN-No:
Non-Hazardous - /

Oltipraz, originally identified as an antischistosomiasis agent, is a potent anticarcinogen in a variety of animal models of cancer at concentrations of ~200 mg/kg.{24177} It is an effective inducer of phase I and II detoxifying enzymes, including glutathione S-transferases, UDP-glucuronosyltransferases, NAD(P)H:quinone oxidoreductase, microsomal epoxide hydrolase, and aflatoxin aldehyde reductase.{24177,24178} Induction of these metabolic enzymes by oltipraz has been linked to the transcription factor nuclear factor E2-related factor 2 and its activation of the antioxidant response element.{24177} In mice, oltipraz at 150 mg/kg can also induce expression of CYP2B, a gene regulated by the constitutive androstane receptor, a transcription factor important in the detoxification of endobiotic and xenobiotic substances.{24179}  

 

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Description

A potent anticarcinogen that effectively induces phase I and II detoxifying enzymes and has been linked to activating the transcription factors Nrf2 and CAR

Formal name: 4-methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione

Synonyms:  NSC 347901|RP 35972

Molecular weight: 226.3

CAS: 64224-21-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer|Transcription Factors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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