Phosphatidylethanolamines (PEs) are phospholipids found in biological membranes that serve both structural and functional roles.{24442,24441} Different types of PE are commonly used in the generation of micelles, liposomes, and other types of artificial membranes.{24443,24444} 1,2-Diphytanoyl-sn-glycero-3-PE is a phospholipid containing the tetramethylated long-chain (16:0) diphytanic acid inserted at the sn-1 and sn-2 positions.
A phospholipid containing the tetramethylated long-chain (16:0) diphytanic acid inserted at the sn-1 and sn-2 positions
Formal name: 1,2-diphytanoyl-sn-glycero-3-phosphatidylethanolamine
Synonyms: 1,2-Diphytanoyl-sn-glycero-3-Phosphoethanolamine|DPyPE
Molecular weight: 804.2
CAS: 201036-16-0
Purity: ≥95%
Formulation: A waxy solid
Product Type|Biochemicals|Lipids|Glycerophospholipids||Research Area|Lipid Biochemistry|Glycerophospholipids
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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