A potent

HPOB – 5 mg

Brand:
Cayman
CAS:
1429651-50-2
Storage:
-20
UN-No:
Non-Hazardous - /

HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).{28379} It is at least 30-fold less effective against other HDACs.{28379} Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones.{28379} HPOB reduces the growth, but not the viability, of normal and transformed cells.{28379} It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin.{28379} HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA (Item No. 10009929) against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft.{28379}  

 

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Description

A potent, selective inhibitor of HDAC6 (IC50 = 56 nM); induces acetylation of α-tubulin but not histones; enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft

Formal name: 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide

Synonyms: 

Molecular weight: 314.3

CAS: 1429651-50-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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