An antiarrythmic agent that inhibits potassium channels; an inhibitor of the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes); has pro-arrhythmic activity at 1 µM

Dofetilide – 5 mg

Brand:
Cayman
CAS:
115256-11-6
Storage:
-20
UN-No:
Non-Hazardous - /

Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes).{24130} However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg.{24131} Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.{24132}  

 

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Description

An antiarrythmic agent that inhibits potassium channels; an inhibitor of the rapidly activating inward rectifying component of net delayed rectifier K+ current (IC50 = 31.5 nM in guinea pig cardiomyocytes); has pro-arrhythmic activity at 1 µM, inducing early afterdepolarizations in cells and Torsade de Pointes in a rabbit screen for proarrhythmic properties at a dose of 10 mg/kg

Formal name: N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide

Synonyms:  Tikosyn|UK 68789

Molecular weight: 441.6

CAS: 115256-11-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Arrhythmia

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