A reversible

Monastrol – 5 mg

Brand:
Cayman
CAS:
329689-23-8
Storage:
-20
UN-No:
Non-Hazardous - /

Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 μM).{8354,24107} It arrests cells in mitosis without targeting tubulin and, as a result, does not interfere with microtubule dependent processes.{24106} Monastrol induces activation of the spindle assembly checkpoint and the resulting mitotic arrest can lead to cell death in certain tumor cell lines.{22151}  

 

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Description

A reversible, cell-permeable inhibitor of the motor protein Eg5, blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 μM)

Formal name: 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 292.4

CAS: 329689-23-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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