A potent antioxidant that inhibits the oxidation of cholesterol in LDL and HDL by impairing the translocation of ABCA1 from intracellular compartments to the plasma membrane

Probucol – 25 g

Brand:
Cayman
CAS:
23288-49-5
Storage:
-20
UN-No:
Non-Hazardous - /

Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.{24123} Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.{24123} Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.{24125} In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.{24124}  

 

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Description

A potent antioxidant that inhibits the oxidation of cholesterol in LDL and HDL by impairing the translocation of ABCA1 from intracellular compartments to the plasma membrane

Formal name: 4,4′-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol

Synonyms:  DH 581|Lorelco|NSC 652160|NSC 86225

Molecular weight: 516.8

CAS: 23288-49-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase

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