A general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 μM

Mibefradil (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
116666-63-8
Storage:
-20
UN-No:
Non-Hazardous - /

Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 μM, respectively).{23964,23965,23967} It is a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM.{23965} Mibefradil has minimal negative inotropic effects, supporting its use as an anti-hypertensive agent.{23965,23966}  

 

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Description

A general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 μM, respectively); a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM

Formal name: (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester 2-methoxy-acetic acid, dihydrochloride

Synonyms:  Posicor|Ro 40-5967

Molecular weight: 568.6

CAS: 116666-63-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation

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