A prodrug form of 5-aminosalicylic acid; inhibits TNF-α and LPS-induced NF-κB activation in SW620 colon cancer cells at 0.1-5 mM; inhibits cystine uptake through the system xc- cysteine-glutamate transporter at 0.25 mM and inhibits the growth of U-87MG glioma cells in an NF-κB independent manner at 0.25-1 mM; decreases diarrhea

Sulfasalazine – 10 g

Brand:
Cayman
CAS:
599-79-1
Storage:
-20
UN-No:
Non-Hazardous - /

Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Item No. 70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond.{22572} This bond is rapidly cleaved by bacteria in the terminal ileum and colon, releasing the active anti-inflammatory component. Sulfasalazine (0.1-5 mM) inhibits TNF-α and LPS-induced NF-κB activation in SW620 colon cancer cells.{9108} It also inhibits degradation of IκBα and prevents nuclear translocation of NF-κB induced by TNF-α. Sulfasalazine (0.25 mM) inhibits cystine uptake through the system xc- cysteine-glutamate transporter and inhibits the growth of U-87MG glioma cells in an NF-κB independent manner when used at concentrations ranging from 0.25 to 1 mM.{48002} Sulfasalazine (100 mg/kg) decreases diarrhea, increases food intake, and reverses body weight decreases in a mouse model of colitis.{22572} It is also suppresses antigen-induced arthritis in mice.{48003} Formulations containing sulfasalazine have been used in the treatment of ulcerative colitis and rheumatoid arthritis.  

 

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Description

A prodrug form of 5-aminosalicylic acid; inhibits TNF-α and LPS-induced NF-κB activation in SW620 colon cancer cells at 0.1-5 mM; inhibits cystine uptake through the system xc- cysteine-glutamate transporter at 0.25 mM and inhibits the growth of U-87MG glioma cells in an NF-κB independent manner at 0.25-1 mM; decreases diarrhea, increases food intake, and reverses body weight decreases in a mouse model of colitis at 100 mg/kg; suppresses antigen-induced arthritis in mice

Formal name: 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-benzoic acid

Synonyms:  Azopyrin|NSC 203730|NSC 667219

Molecular weight: 398.4

CAS: 599-79-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis

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