A potent

PF-04981517 – 10 mg

Brand:
Cayman
CAS:
1390637-82-7
Storage:
-20
UN-No:
Non-Hazardous - /

PF-04981517 is a potent, time-dependent inhibitor of the cytochrome P450 (CYP450) isoform CYP3A4 (IC50 = 30 nM).{22614} It is less effective against CYP3A5 and CYP3A7 (IC50s = 17 and 70 μM, respectively).{22614} PF-04981517 will be useful for understanding the relative roles of CYP3A4 and CYP3A5 in drug metabolism.  

 

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Description

A potent, selective, and time-dependent inhibitor of CYP3A4 (IC50 = 30 nM)

Formal name: 1-methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-(1-piperidinyl)-1-pyrrolidinyl]-1H-pyrazolo[3,4-d]pyrimidine

Synonyms:  CYP3cide

Molecular weight: 456.6

CAS: 1390637-82-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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