A specific

PF-04708671 – 50 mg

Brand:
Cayman
CAS:
1255517-76-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

P70 ribosomal S6 kinase (S6K1) is a serine/threonine kinase which is activated by insulin and growth factors through PI3K and mTORC1 signaling pathways. PF-04708671 is a specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM).{22617} It does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity.{22617} It is useful in evaluating the role of S6K1 and, indirectly, mTORC1, in cell signaling.{22618,22616}  

 

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Description

A specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM); does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity

Formal name: 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole

Synonyms: 

Molecular weight: 390.4

CAS: 1255517-76-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|S6K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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