An orally active

PF-04418948 – 100 mg

Brand:
Cayman
CAS:
1078166-57-0
Storage:
-20
UN-No:
Non-Hazardous - /

Prostaglandin E2 (PGE2) evokes distinct responses through four different ‘E prostanoid’ (EP) receptors. EP2 is a G protein-coupled receptor which signals preferentially through Gs proteins. PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM).{22584} It is over a thousand-fold less active at other prostanoid receptors, including other EP receptors. PF-04418948 can be used in cells and tissues.{22583,22585} In rats, it significantly reduces the effects of the EP2-selective agonist butaprost on cutaneous blood flow when given orally.{22584}  

 

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Description

An orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM); over 1,000-fold less active at other prostanoid receptors, including other EP receptors

Formal name: 1-(4-fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

Synonyms: 

Molecular weight: 409.4

CAS: 1078166-57-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Vasculature||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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